Mast cell recruitment is modulated by the hairless skin microbiome

Chia-Chi Wu; Ji-Nu Kim; Zhenping Wang; Yu-Ling Chang; Karsten Zengler; Anna Di Nardo

doi:10.1016/j.jaci.2019.02.033

Mast cell recruitment is modulated by the hairless skin microbiome

J Allergy Clin Immunol. 2019 Jul;144(1):330-333.e6. doi: 10.1016/j.jaci.2019.02.033. Epub 2019 Mar 27.

Authors

Chia-Chi Wu¹, Ji-Nu Kim², Zhenping Wang¹, Yu-Ling Chang¹, Karsten Zengler², Anna Di Nardo³

Affiliations

¹ Department of Dermatology, University of California, San Diego, La Jolla, Calif.
² Department of Pediatrics, University of California, San Diego, La Jolla, Calif.
³ Department of Dermatology, University of California, San Diego, La Jolla, Calif. Electronic address: adinardo@ucsd.edu.

Abstract

Hairless mice have countless mast cells (MCs) in the skin and a more gram positive microbiome (GPM). MC number normalizes when TLR2, a GPM sensor, is deleted, proving a connection between hair-loss, GPM and MCs.

Publication types

Letter
Research Support, N.I.H., Extramural

MeSH terms

Animals
Coculture Techniques
Fibroblasts / immunology
Mast Cells / immunology*
Mice, Hairless
Mice, Inbred C57BL
Mice, Knockout
Microbiota*
Skin / immunology*
Skin / microbiology*
Staphylococcus epidermidis*
Toll-Like Receptor 2 / genetics
Toll-Like Receptor 2 / immunology

Substances

Tlr2 protein, mouse
Toll-Like Receptor 2

Abstract

Publication types

MeSH terms

Substances

Grants and funding