Programming Motions of DNA Origami Nanomachines

Fei Wang; Xueli Zhang; Xiaoguo Liu; Chunhai Fan; Qian Li

doi:10.1002/smll.201900013

Programming Motions of DNA Origami Nanomachines

Small. 2019 Jun;15(26):e1900013. doi: 10.1002/smll.201900013. Epub 2019 Mar 25.

Authors

Fei Wang^{1

2}, Xueli Zhang¹, Xiaoguo Liu², Chunhai Fan², Qian Li²

Affiliations

¹ Joint Research Center for Precision Medicine, Shanghai Jiao Tong University and Affiliated Sixth People's Hospital South Campus, Southern Medical University Affiliated Fengxian Hospital, Shanghai, 201499, China.
² School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.

PMID: 30908896
DOI: 10.1002/smll.201900013

Abstract

DNA nanotechnology enables the precise fabrication of DNA-based machines with nanoscale dimensions. A wide range of DNA nanomachines are designed, which can be activated by specific inputs to perform various movement and functions. The excellent rigidity and unprecedented addressability of DNA origami have made it an excellent platform for manipulating and investigating the motion behaviors of DNA machines at single-molecule level. In this Concept, power supply, machine actuation, and motion behavior of DNA machines on origami platforms are summarized and classified. The strategies utilized for programming motion behavior of DNA machines on DNA origami are also discussed with representative examples. The challenges and outlook for future development of manipulating DNA nanomachines at the single molecule level are presented and discussed.

Keywords: DNA nanomachines; DNA nanotechnology; DNA origami; molecule manipulation; motion behavior.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

DNA / chemistry*
Nanostructures / chemistry*
Nanotechnology / methods*

Substances

DNA