Structure-based drug discovery by targeting N-glycan biosynthesis, dolichyl-phosphate N-acetylglucosaminephosphotransferase

Future Med Chem. 2019 May;11(9):927-933. doi: 10.4155/fmc-2018-0405. Epub 2019 Mar 25.
No abstract available

Keywords: DPAGT1; anticancer drugs; co-crystal structures; inhibitors; structure-based drug design.

Publication types

  • Editorial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biosynthetic Pathways / drug effects
  • Drug Design*
  • Drug Discovery
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Humans
  • Molecular Docking Simulation
  • N-Acetylglucosaminyltransferases / antagonists & inhibitors*
  • N-Acetylglucosaminyltransferases / chemistry
  • N-Acetylglucosaminyltransferases / metabolism
  • Polysaccharides / metabolism*

Substances

  • Enzyme Inhibitors
  • Polysaccharides
  • N-Acetylglucosaminyltransferases
  • dolichyl-phosphate alpha-N-acetylglucosaminyltransferase