Emerging roles of lncRNAs in the post-transcriptional regulation in cancer

Rong-Zhang He; Di-Xian Luo; Yin-Yuan Mo

doi:10.1016/j.gendis.2019.01.003

Emerging roles of lncRNAs in the post-transcriptional regulation in cancer

Genes Dis. 2019 Feb 11;6(1):6-15. doi: 10.1016/j.gendis.2019.01.003. eCollection 2019 Mar.

Authors

Rong-Zhang He^{1

2

3}, Di-Xian Luo², Yin-Yuan Mo³

Affiliations

¹ Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410078 Hunan, China.
² Translational Medicine Institute, National & Local Joint Engineering Laboratory for High-through Molecular Diagnosis Technology, Collaborative Research Center for Post-doctoral Mobile Stations of Central South University, Affiliated the First People's Hospital of Chenzhou of University of South China, Chenzhou, 432000, China.
³ Department of Pharmacology/Toxicology, and Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA.

Abstract

Accumulating evidence indicates that long non-coding RNAs (lncRNAs) can play a pivotal role in regulation of diverse cellular processes. In particular, lncRNAs can serve as master gene regulators at transcriptional and posttranscriptional levels, leading to tumorigenesis. In this review, we discuss latest developments in lncRNA-meditated gene expression at the post-transcriptional level, including gene splicing, mRNA stability, protein stability and nuclear trafficking.

Keywords: Alternative splicing; LncRNA; Posttranscriptional regulation; Protein stability; RNA binding proteins; RNA stability.

Publication types

Review