The FOXP3Δ2 isoform supports Treg cell development and protects against severe IPEX syndrome

J Allergy Clin Immunol. 2019 Jul;144(1):317-320.e8. doi: 10.1016/j.jaci.2019.03.003. Epub 2019 Mar 21.
No abstract available

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Diabetes Mellitus, Type 1 / congenital*
  • Diabetes Mellitus, Type 1 / immunology
  • Diarrhea / immunology*
  • Female
  • Forkhead Transcription Factors / genetics*
  • Forkhead Transcription Factors / immunology
  • Frameshift Mutation
  • Genetic Diseases, X-Linked / immunology*
  • Humans
  • Immune System Diseases / congenital*
  • Immune System Diseases / immunology
  • Male
  • Protein Isoforms / genetics
  • Protein Isoforms / immunology
  • T-Lymphocytes, Regulatory / immunology*

Substances

  • FOXP3 protein, human
  • Forkhead Transcription Factors
  • Protein Isoforms

Supplementary concepts

  • Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome