Human MLL/KMT2A gene exhibits a second breakpoint cluster region for recurrent MLL-USP2 fusions

Claus Meyer; Bruno A Lopes; Aurélie Caye-Eude; Hélène Cavé; Chloé Arfeuille; Wendy Cuccuini; Rosemary Sutton; Nicola C Venn; Seung Hwan Oh; Grigory Tsaur; Gabriele Escherich; Tobias Feuchtinger; Hansen J Kosasih; Seong L Khaw; Paul G Ekert; Maria S Pombo-de-Oliveira; Audrey Bidet; Bardya Djahanschiri; Ingo Ebersberger; Marketa Zaliova; Jan Zuna; Zuzana Zermanova; Vesa Juvonen; Renate Panzer Grümayer; Grazia Fazio; Gianni Cazzaniga; Patrizia Larghero; Mariana Emerenciano; Rolf Marschalek

doi:10.1038/s41375-019-0451-7

Human MLL/KMT2A gene exhibits a second breakpoint cluster region for recurrent MLL-USP2 fusions

Leukemia. 2019 Sep;33(9):2306-2340. doi: 10.1038/s41375-019-0451-7. Epub 2019 Mar 21.

Authors

Claus Meyer¹, Bruno A Lopes^{1

2}, Aurélie Caye-Eude³, Hélène Cavé³, Chloé Arfeuille³, Wendy Cuccuini⁴, Rosemary Sutton⁵, Nicola C Venn⁵, Seung Hwan Oh^{1

6}, Grigory Tsaur⁷, Gabriele Escherich⁸, Tobias Feuchtinger⁹, Hansen J Kosasih¹⁰, Seong L Khaw¹⁰, Paul G Ekert^{5

10}, Maria S Pombo-de-Oliveira¹¹, Audrey Bidet¹², Bardya Djahanschiri¹³, Ingo Ebersberger^{13

14}, Marketa Zaliova¹⁵, Jan Zuna¹⁵, Zuzana Zermanova¹⁶, Vesa Juvonen¹⁷, Renate Panzer Grümayer¹⁸, Grazia Fazio¹⁹, Gianni Cazzaniga¹⁹, Patrizia Larghero¹, Mariana Emerenciano², Rolf Marschalek²⁰

Affiliations

¹ DCAL/Institute of Pharmaceutical Biology, Goethe-University Frankfurt, Frankfurt am Main, Germany.
² Division of Clinical Research, Research Center, Instituto Nacional de Cancer, Rio de Janeiro, Brazil.
³ Department of Genetics, AP-HP Robert Debré, Paris Diderot University, Paris, France.
⁴ Department of Cytogenetics, Saint Louis Hospital, Paris, France.
⁵ Children's Cancer Institute Australia, University of NSW Sydney, Sydney, Australia.
⁶ Department of Laboratory Medicine, Inje University College of Medicine, Busan, Korea.
⁷ Regional Children Hospital 1, Research Institute of Medical Cell Technologies, Pediatric Oncology and Hematology Center, Ural Federal University named after the first President of Russia BN Yeltsin, Ekaterinburg, Russia.
⁸ Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
⁹ Department of Pediatric Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Dr. von Hauner University Children's Hospital, Ludwig Maximilian University Munich, Munich, Germany.
¹⁰ Murdoch Children's Research Institute, The Royal Children's Hospital, Flemington Road Parkville, 3052, Victoria, Australia.
¹¹ Pediatric Hematology-Oncology Program-Research Center, Instituto Nacional de Cancer Rio de Janeiro, Rio de Janeiro, Brazil.
¹² Laboratoire d'Hématologie, University Hospital, Brest, CHU de Bordeaux, Bordeaux, France.
¹³ Department of Applied Bioinformatics, Institute of Cell Biology and Neuroscience, Goethe-Universität Frankfurt, Frankfurt am Main, 60438, Germany.
¹⁴ Senckenberg Climate and Research Centre (BIK-F), Frankfurt am Main, 60325, Germany.
¹⁵ CLIP, Department of Paediatric Haematology/Oncology, Charles University Prague, 2nd Faculty of Medicine, Prague, Czech Republic.
¹⁶ Center of Oncocytogenetics, Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic.
¹⁷ Department of Clinical Chemistry and Laboratory Division, Turku University Hospital, Turku, Finland.
¹⁸ Children's Cancer Research Institute, Medical University of Vienna, Vienna, Austria.
¹⁹ Centro Ricerca Tettamanti, Clinica Pediatrica University of Milano-Bicocca, Monza, Italy.
²⁰ DCAL/Institute of Pharmaceutical Biology, Goethe-University Frankfurt, Frankfurt am Main, Germany. rolf.marschalek@em.uni-frankfurt.de.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Cohort Studies
Histone-Lysine N-Methyltransferase / genetics*
Humans
Leukemia / genetics
Myeloid-Lymphoid Leukemia Protein / genetics*
Recombinant Fusion Proteins / genetics*
Translocation, Genetic / genetics
Ubiquitin Thiolesterase / genetics*

Substances

KMT2A protein, human
Recombinant Fusion Proteins
Myeloid-Lymphoid Leukemia Protein
Histone-Lysine N-Methyltransferase
USP2 protein, human
Ubiquitin Thiolesterase