Effective and Reliable Framework for Lung Nodules Detection from CT Scan Images

Sci Rep. 2019 Mar 21;9(1):4989. doi: 10.1038/s41598-019-41510-9.

Abstract

Lung cancer is considered more serious among other prevailing cancer types. One of the reasons for it is that it is usually not diagnosed until it has spread and by that time it becomes very difficult to treat. Early detection of lung cancer can significantly increase the chances of survival of a cancer patient. An effective nodule detection system can play a key role in early detection of lung cancer thus increasing the chances of successful treatment. In this research work, we have proposed a novel classification framework for nodule classification. The framework consists of multiple phases that include image contrast enhancement, segmentation, optimal feature extraction, followed by employment of these features for training and testing of Support Vector Machine. We have empirically tested the efficacy of our technique by utilizing the well-known Lung Image Consortium Database (LIDC) dataset. The empirical results suggest that the technique is highly effective for reducing the false positive rates. We were able to receive an impressive sensitivity rate of 97.45%.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Early Detection of Cancer*
  • Humans
  • Lung / diagnostic imaging
  • Lung / pathology
  • Lung Neoplasms / diagnosis*
  • Lung Neoplasms / diagnostic imaging
  • Lung Neoplasms / pathology
  • Precancerous Conditions / diagnosis*
  • Precancerous Conditions / diagnostic imaging
  • Precancerous Conditions / pathology
  • Solitary Pulmonary Nodule / diagnosis*
  • Solitary Pulmonary Nodule / diagnostic imaging
  • Solitary Pulmonary Nodule / pathology
  • Support Vector Machine
  • Tomography, X-Ray Computed