Ubiquitin Ligases in Cancer Immunotherapy - Balancing Antitumor and Autoimmunity

Trends Mol Med. 2019 May;25(5):428-443. doi: 10.1016/j.molmed.2019.02.002. Epub 2019 Mar 18.

Abstract

Considerable progress has been made in understanding the contribution of E3 ubiquitin ligases to health and disease, including the pathogenesis of immunological disorders. Ubiquitin ligases exert exquisite spatial and temporal control over protein stability and function, and are thus crucial for the regulation of both innate and adaptive immunity. Given that immune responses can be both detrimental (autoimmunity) and beneficial (antitumor immunity), it is vital to understand how ubiquitin ligases maintain immunological homeostasis. Such knowledge could reveal novel mechanisms underlying immune regulation and identify new therapeutic approaches to enhance antitumor immunity and safeguard against autoimmunity.

Keywords: E3 ubiquitin ligase; antitumor immunity; autoimmunity; immune checkpoint.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Autoimmunity
  • Biomarkers, Tumor
  • Humans
  • Immune Tolerance
  • Immunity
  • Immunologic Surveillance
  • Immunomodulation
  • Immunotherapy
  • Lymphocyte Activation / genetics
  • Lymphocyte Activation / immunology
  • Neoplasms / immunology*
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Neoplasms / therapy
  • Signal Transduction
  • T-Lymphocytes / immunology
  • T-Lymphocytes / metabolism
  • Tumor Escape
  • Ubiquitin / metabolism*
  • Ubiquitin-Protein Ligase Complexes / metabolism*
  • Ubiquitin-Protein Ligases / metabolism
  • Ubiquitination

Substances

  • Biomarkers, Tumor
  • Ubiquitin
  • Ubiquitin-Protein Ligase Complexes
  • Ubiquitin-Protein Ligases