Inflaming the Brain

Hyung Jin Ahn; Sarah K Baker; Erin H Norris; Sidney Strickland

doi:10.1016/j.neuron.2019.03.007

Inflaming the Brain

Neuron. 2019 Mar 20;101(6):991-993. doi: 10.1016/j.neuron.2019.03.007.

Authors

Hyung Jin Ahn¹, Sarah K Baker², Erin H Norris², Sidney Strickland³

Affiliations

¹ Department of Pharmacology, Physiology and Neurosciences, Rutgers-New Jersey Medical School, Newark, NJ 07103, USA; Brain Health Institute, Rutgers University, Piscataway, NJ 08854, USA.
² Patricia and John Rosenwald Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, NY 10065, USA.
³ Patricia and John Rosenwald Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, NY 10065, USA. Electronic address: strickland@rockefeller.edu.

PMID: 30897363
DOI: 10.1016/j.neuron.2019.03.007

Abstract

Exactly how cerebrovascular alterations contribute to Alzheimer's disease (AD) is still unknown. Merlini et al. (2019) show that blood-derived fibrinogen leads to dendritic spine elimination and cognitive deficit via microglial CD11b/CD18. Fibrinogen may be a significant contributor to AD pathogenesis.

Publication types

Comment

MeSH terms

Alzheimer Disease*
Brain
Cognitive Dysfunction*
Fibrinogen
Humans
Microglia

Substances

Fibrinogen

Grants and funding

R01 NS104386/NS/NINDS NIH HHS/United States