Circular RNAs as promising biomarkers in cancer: detection, function, and beyond

Shengli Li; Leng Han

doi:10.1186/s13073-019-0629-7

Circular RNAs as promising biomarkers in cancer: detection, function, and beyond

Genome Med. 2019 Mar 20;11(1):15. doi: 10.1186/s13073-019-0629-7.

Authors

Shengli Li¹, Leng Han^{2

3}

Affiliations

¹ Department of Biochemistry and Molecular Biology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
² Department of Biochemistry and Molecular Biology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA. leng.han@uth.tmc.edu.
³ Center for Precision Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA. leng.han@uth.tmc.edu.

Abstract

Circular RNAs (circRNAs) are 3'-5' covalently closed RNA rings produced from back-splicing of precursor mRNA in eukaryotes. Recent studies, using both computational and experimental approaches, have allowed advanced characterization of circRNAs, leading the research field into a new era and shedding light on the contribution of circRNAs to disease.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biomarkers, Tumor / genetics*
Colorectal Neoplasms / genetics*
Gene Expression Regulation, Neoplastic
Humans
RNA, Circular / genetics*

Substances

Biomarkers, Tumor
RNA, Circular