The role of the nervous system in the pathogenesis of psoriasis is not well elucidated. However, its involvement is clinically apparent with sparing of areas affected by neurologic disease, such as poliomyelitis, and remission of psoriasis in cases of nerve damage. Several neuropeptides, including substance P (SP), nerve growth factor, calcitonin gene-related peptide, and vasoactive intestinal peptide have been hypothesized to play a part in the development of psoriasis and its symptoms. We report a case of a patient with psoriasis who experienced complete remission following ischemic stroke.