Associations between H19 polymorphisms and neuroblastoma risk in Chinese children

Biosci Rep. 2019 Apr 5;39(4):BSR20181582. doi: 10.1042/BSR20181582. Print 2019 Apr 30.

Abstract

BackgroundH19 polymorphisms have been reported to correlate with an increased susceptibility to a few types of cancers, although their role in neuroblastoma has not yet been clarified.Materials and methods We investigated the association between three single polymorphisms (rs2839698 G>A, rs3024270 C>G, and rs217727 G>A) and neuroblastoma susceptibility in Chinese Han populations. Three hundred ninety-three neuroblastoma patients and 812 healthy controls were enrolled from the Henan and Guangdong provinces. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to determine the strength of the association of interest.Results Separated and combined analyses revealed no associations of the rs2839698 G>A, rs3024270 C>G or rs217727 G>A polymorphisms and neuroblastoma susceptibility. In the stratification analysis, female children with rs3024270 GG genotypes had an increased neuroblastoma risk (adjusted OR = 1.61, 95% CI = 1.04-2.50, P=0.032).Conclusion The rs3024270 GG genotype might contribute to an increased neuroblastoma susceptibility in female Chinese children.

Keywords: H19; SNP; long noncoding RNA; neuroblastoma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinogenesis / genetics
  • Case-Control Studies
  • Child
  • China / epidemiology
  • Female
  • Genetic Predisposition to Disease / genetics*
  • Genotype
  • Humans
  • Male
  • Neuroblastoma / epidemiology*
  • Neuroblastoma / genetics*
  • Polymorphism, Single Nucleotide / genetics*
  • RNA, Long Noncoding / genetics*

Substances

  • H19 long non-coding RNA
  • RNA, Long Noncoding