Malignant Peripheral Nerve Sheath Tumor With Bilateral Adrenal Metastases: Role of 18F-FDG PET/CT in Response Assessment to Tyrosine Kinase Inhibitor and Liposomal Doxorubicin

Clin Nucl Med. 2019 Jun;44(6):494-495. doi: 10.1097/RLU.0000000000002542.

Abstract

MPNSTs (malignant peripheral nerve sheath tumors) are a highly malignant group of soft tissue sarcomas and carry a very poor prognosis. Metastasis to bilateral adrenal glands is very rare in such group of neoplasms. We discuss a case of 85-year-old man who was diagnosed with MPNST from prevertebral mass with metastases to bilateral adrenal glands and bone marrow from the beginning and role of serial F-FDG PET/CT scans in response assessment first to sunitinib (tyrosine kinase inhibitor) and then to liposomal doxorubicin.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Gland Neoplasms / diagnostic imaging*
  • Adrenal Gland Neoplasms / secondary
  • Aged, 80 and over
  • Antineoplastic Agents / therapeutic use
  • Doxorubicin / therapeutic use
  • Fluorodeoxyglucose F18
  • Humans
  • Male
  • Nerve Sheath Neoplasms / diagnostic imaging*
  • Nerve Sheath Neoplasms / drug therapy
  • Nerve Sheath Neoplasms / pathology
  • Neurofibrosarcoma / diagnostic imaging*
  • Neurofibrosarcoma / drug therapy
  • Neurofibrosarcoma / pathology
  • Positron Emission Tomography Computed Tomography*
  • Radiopharmaceuticals

Substances

  • Antineoplastic Agents
  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18
  • Doxorubicin