Species Distribution and Macrolide Susceptibility of Mycobacterium fortuitum Complex Clinical Isolates

Su-Young Kim; Seong Mi Moon; Byung Woo Jhun; O Jung Kwon; Hee Jae Huh; Nam Yong Lee; Seung Heon Lee; Sung Jae Shin; Shannon H Kasperbauer; Gwen A Huitt; Charles L Daley; Won-Jung Koh

doi:10.1128/AAC.02331-18

Species Distribution and Macrolide Susceptibility of Mycobacterium fortuitum Complex Clinical Isolates

Antimicrob Agents Chemother. 2019 May 24;63(6):e02331-18. doi: 10.1128/AAC.02331-18. Print 2019 Jun.

Authors

Su-Young Kim^#¹, Seong Mi Moon^#¹, Byung Woo Jhun¹, O Jung Kwon¹, Hee Jae Huh², Nam Yong Lee², Seung Heon Lee³, Sung Jae Shin^{4

5}, Shannon H Kasperbauer^{6

7}, Gwen A Huitt^{6

7}, Charles L Daley^{6

7

8}, Won-Jung Koh⁹

Affiliations

¹ Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
² Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
³ Korean Institute of Tuberculosis, Cheongju, South Korea.
⁴ Department of Microbiology, Yonsei University College of Medicine, Seoul, South Korea.
⁵ Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea.
⁶ Division of Mycobacterial and Respiratory Infections, Department of Medicine, National Jewish Health, Denver, Colorado, USA.
⁷ Division of Infectious Disease, Department of Medicine, University of Colorado, Aurora, Colorado, USA.
⁸ Division of Pulmonary Sciences and Critical Care, Department of Medicine, University of Colorado, Aurora, Colorado, USA.
⁹ Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea wjkoh@skku.edu.

^# Contributed equally.

Abstract

The understanding of species distribution and inducible macrolide resistance in the Mycobacterium fortuitum complex (MFC) is limited. Of 90 mostly respiratory MFC clinical isolates, half were M. fortuitum, followed by M. peregrinum, M. porcinum, M. septicum, and M. conceptionense Most M. fortuitum, M. porcinum, and M. septicum isolates were inducibly resistant to clarithromycin, whereas two-thirds of the M. peregrinum isolates were clarithromycin susceptible. Clarithromycin-resistant M. fortuitum isolates exhibited common mutations of erm(39), potentially involved in clarithromycin resistance.

Keywords: Mycobacterium fortuitum complex; clarithromycin; drug resistance; nontuberculous mycobacteria.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology*
Clarithromycin / pharmacology*
Drug Resistance, Bacterial
Microbial Sensitivity Tests
Mycobacterium fortuitum / drug effects*

Substances

Anti-Bacterial Agents
Clarithromycin