Pseudomonas aeruginosa severe skin infection in a toddler with X-linked agammaglobulinemia due to a novel BTK mutation

Infez Med. 2019 Mar 1;27(1):73-76.

Abstract

Agammaglobulinemia is a congenital deficit of humoral immunity characterized by a decreased level or complete absence of immunoglobulins and profound reduction of B-lymphocytes associated with an increased risk of life-threatening bacterial infection. We report a case of invasive Pseudomonas aeruginosa severe skin and soft tissue infection treated with vacuum-assisted closure and antibiotics in a toddler with a previously unreported mutation of the Bruton tyrosin kinase gene.

Publication types

  • Case Reports

MeSH terms

  • Agammaglobulinaemia Tyrosine Kinase / genetics*
  • Agammaglobulinemia / genetics*
  • Genetic Diseases, X-Linked / genetics*
  • Humans
  • Infant
  • Leg Ulcer / therapy
  • Male
  • Mutation
  • Negative-Pressure Wound Therapy
  • Pseudomonas Infections / microbiology*
  • Pseudomonas Infections / therapy
  • Pseudomonas aeruginosa*
  • Skin Diseases, Bacterial / microbiology*
  • Skin Diseases, Bacterial / therapy

Substances

  • Agammaglobulinaemia Tyrosine Kinase
  • BTK protein, human

Supplementary concepts

  • Bruton type agammaglobulinemia