Probable Donor-Derived Human Adenovirus Type 34 Infection in 2 Kidney Transplant Recipients From the Same Donor

Open Forum Infect Dis. 2018 Dec 26;6(3):ofy354. doi: 10.1093/ofid/ofy354. eCollection 2019 Mar.

Abstract

Human adenovirus type 34 (HAdV-34) infection is a recognized cause of transplant-associated hemorrhagic cystitis and, in rare cases, tubulointerstitial nephritis. The source of such infections is often difficult to assess, that is, whether acquired as a primary infection, exposure to a pathogen in the transplanted organ, or reactivation of an endogenous latent infection. We present here 2 cases of likely transplant-acquired HAdV-34 infection from the same organ donor, manifesting as tubulointerstitial nephritis in 1.

Keywords: HAdV-34; adenovirus; kidney transplant; tubulointerstitial nephritis.