Bidirectional Ultrasound Elastographic Imaging Framework for Non-invasive Assessment of the Non-linear Behavior of a Physiologically Pressurized Artery

Abstract

Studies of non-destructive bidirectional ultrasound assessment of non-linear mechanical behavior of the artery are scarce in the literature. We hereby propose derivation of a strain-shear modulus relationship as a new graphical diagnostic index using an ultrasound elastographic imaging framework, which encompasses our in-house bidirectional vascular guided wave imaging (VGWI) and ultrasound strain imaging (USI). This framework is used to assess arterial non-linearity in two orthogonal (i.e., longitudinal and circumferential) directions in the absence of non-invasive pressure measurement. Bidirectional VGWI estimates longitudinal (μ_L) and transverse (μ_T) shear moduli, whereas USI estimates radial strain (ɛ_r). Vessel-mimicking phantoms (with and without longitudinal pre-stretch) and in vitro porcine aortas under static and/or dynamic physiologic intraluminal pressure loads were examined. ɛ_r was found to be a suitable alternative to intraluminal pressure for representation of cyclic loading on the artery wall. Results revealed that μ_T values of all samples examined increased non-linearly with ε_r magnitude and more drastically than μ_L, whereas μ_L values of only the pre-stretched phantoms and aortas increased with ɛ_r magnitude. As a new graphical representation of arterial non-linearity and function, strain-shear modulus loops derived by the proposed framework over two consecutive dynamic loading cycles differentiated sample pre-conditions and corroborated direction-dependent non-linear mechanical behaviors of the aorta with high estimation repeatability.

Keywords: Artery; Elastography; Non-linear; Shear modulus; Strain; Ultrasound.