A palladium-catalyzed multi-component annulation approach towards the synthesis of phenanthrenes

Org Biomol Chem. 2019 Mar 27;17(13):3328-3332. doi: 10.1039/c9ob00228f.

Abstract

An efficient palladium-catalyzed three-component cascade reaction has been developed for the facile construction of phenanthrene frameworks. The transformation is driven by a controlled reaction sequence of Suzuki-Miyaura coupling followed by the insertion of alkynes, and finally, annulation to yield phenanthrene derivatives via C-H activation. This methodology is able to accommodate a variety of substrates and affords the anticipated products in good to excellent yields.

Publication types

  • Research Support, Non-U.S. Gov't