Aquaporin-4 Expression Patterns in Glioblastoma Pre-Chemoradiation and at Time of Suspected Progression

Michael Levy; Scott Barletta; Hwa Huang; Stuart A Grossman; Fausto J Rodriguez; Susannah G Ellsworth; Omar Dzaye; Matthias Holdhoff

doi:10.1080/07357907.2018.1564927

Aquaporin-4 Expression Patterns in Glioblastoma Pre-Chemoradiation and at Time of Suspected Progression

Cancer Invest. 2019;37(2):67-72. doi: 10.1080/07357907.2018.1564927. Epub 2019 Mar 15.

Authors

Michael Levy^{1

2}, Scott Barletta¹, Hwa Huang¹, Stuart A Grossman³, Fausto J Rodriguez⁴, Susannah G Ellsworth⁵, Omar Dzaye^{3

6

7}, Matthias Holdhoff³

Affiliations

¹ a Department of Neurology , Johns Hopkins University , Baltimore , MD , USA.
² b Department of Neurology , Massachusetts General Hospital, Harvard Medical School , Boston , MA , USA.
³ c Department of Oncology , Johns Hopkins University , Baltimore , MD , USA.
⁴ d Department of Pathology , Johns Hopkins University , Baltimore , MD , USA.
⁵ e Department of Radiation Oncology , Indiana University School of Medicine , Indianapolis , IN , USA.
⁶ f Russell H. Morgan Department of Radiology and Radiological Science , Johns Hopkins University School of Medicine , Baltimore , MD , USA.
⁷ g Department of Radiology and Neuroradiology , Charité , Berlin , Germany.

PMID: 30873889
DOI: 10.1080/07357907.2018.1564927

Abstract

There has been controversy about the presence and potential role of aquaporin-4 (AQP4) in glioblastoma (GBM). We analyzed tissue from 22 patients with newly-diagnosed GBM as well as matching tissue from 17 of these cases who underwent repeat resection for suspected recurrence and performed immunohistochemical analysis for AQP-4 expression. While some degree of AQP4 expression was detected in all 22 cases (39 samples), there was no clear relationship between staining pattern and disease status (active versus inactive GBM) between baseline and time of repeat biopsy. In addition, there was no clear relationship between AQP4 expression and degree of edema.

Keywords: AQP4; Aquaporin-4; Edema; Glioblastoma.

MeSH terms

Adult
Aged
Aquaporin 4 / metabolism*
Biopsy
Brain Neoplasms / metabolism*
Brain Neoplasms / pathology
Chemoradiotherapy / methods
Disease Progression
Edema / metabolism
Edema / pathology
Female
Gene Expression Regulation, Neoplastic / physiology
Glioblastoma / metabolism*
Glioblastoma / pathology
Glioma / metabolism
Glioma / pathology
Humans
Male
Middle Aged
Neoplasm Recurrence, Local / metabolism
Neoplasm Recurrence, Local / pathology
Retrospective Studies

Substances

AQP4 protein, human
Aquaporin 4