Abstract
Mitochondria emerge as an important target for cancer therapy. Herein, by taking advantage of the recently reported high temperature of mitochondria, a well-tuned thermoresponsive nanocarrier was developed for specifically delivering the anticancer drug, paclitaxel (PTX), to mitochondria in cancer cells. The temperature-dependent delivery of drugs to mitochondria represents a novel anticancer strategy.
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / administration & dosage*
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Antineoplastic Agents, Phytogenic / pharmacology
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Cell Line
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Dose-Response Relationship, Drug
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Drug Carriers / chemistry*
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Drug Screening Assays, Antitumor
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Humans
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Mice
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Mitochondria / drug effects
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Mitochondria / metabolism*
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Nanoparticles / chemistry*
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Neoplasms / drug therapy*
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Neoplasms / pathology
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Paclitaxel / administration & dosage*
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Paclitaxel / pharmacology
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Structure-Activity Relationship
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Temperature*
Substances
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Antineoplastic Agents, Phytogenic
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Drug Carriers
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Paclitaxel