Pd(ii)-Catalyzed decarboxylative meta-C-H difluoromethylation

Huaxin Zhao; Guobin Ma; Xiaojuan Xie; Yong Wang; Jian Hao; Wen Wan

doi:10.1039/c9cc00984a

Pd(ii)-Catalyzed decarboxylative meta-C-H difluoromethylation

Chem Commun (Camb). 2019 Apr 7;55(27):3927-3930. doi: 10.1039/c9cc00984a. Epub 2019 Mar 14.

Authors

Huaxin Zhao¹, Guobin Ma², Xiaojuan Xie¹, Yong Wang¹, Jian Hao¹, Wen Wan³

Affiliations

¹ Department of Chemistry, Shanghai University, Shanghai, China. wanwen@shu.edu.cn jhao@shu.edu.cn.
² School of Science, Shanghai University, China.
³ Department of Chemistry, Shanghai University, Shanghai, China. wanwen@shu.edu.cn jhao@shu.edu.cn and Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China.

PMID: 30869687
DOI: 10.1039/c9cc00984a

Abstract

A palladium(ii)-catalyzed decarboxylative meta-selective C-H difluoromethylation of arenes has been developed from easily accessible difluoroacetic acids. Initial mechanistic studies disclosed that a reasonable migratory insertion is involved in this meta-C-H functionalization.