Objective: To setup a three-component tumor growth mathematical model and discuss its basic application in tumor fractional radiotherapy with computer simulation.
Method: First, our three-component tumor growth model extended from the classical Gompertz tumor model was formulated and applied to a fractional radiotherapy with a series of proper parameters. With the computer simulation of our model, the impact of some parameters such as fractional dose, amount of quiescent tumor cells, and α/β value to the effect of radiotherapy was also analyzed, respectively.
Results: With several optimal technologies, the model could run stably and output a series of convergent results. The simulation results showed that the fractional radiotherapy dose could impact the effect of radiotherapy significantly, while the amount of quiescent tumor cells and α/β value did that to a certain extent.
Conclusions: Supported with some proper parameters, our model can simulate and analyze the tumor radiotherapy program as well as give some theoretical instruction to radiotherapy personalized optimization.
Keywords: computer simulation; three-component mathematical model; tumor radiotherapy.
© 2019 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.