Minimal cells, maximal knowledge

Elife. 2019 Mar 12:8:e45379. doi: 10.7554/eLife.45379.

Authors

Jean-Christophe Lachance¹, Sébastien Rodrigue¹, Bernhard O Palsson^{2

3

4

5}

Affiliations

¹ Département de Biologie, Université de Sherbrooke, Sherbrooke, Canada.
² Department of Bioengineering, University of California, San Diego, United States.
³ Department of Pediatrics, University of California, San Diego, United States.
⁴ Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark.
⁵ Bioinformatics and Systems Biology Program, University of California, San Diego, Unites States.

Abstract

Modeling all the chemical reactions that take place in a minimal cell will help us understand the fundamental interactions that power life.

Keywords: JCVI-syn3.0A; computational biology; gene essentiality; mathematical modeling; metabolism; minimal cells; systems biology.

© 2019, Lachance et al.

MeSH terms

Chromosome Mapping*
Computational Biology / methods*
DNA / chemistry*
Gene Expression Regulation
Genes, Essential
Genetics
Genome
Genome, Bacterial
Microbiota
Mycoplasma / genetics
Synthetic Biology*
Systems Biology*

Substances

DNA