In Vitro Activities of Omadacycline against Rapidly Growing Mycobacteria

Carolyn Shoen; David Benaroch; Mary Sklaney; Michael Cynamon

doi:10.1128/AAC.02522-18

In Vitro Activities of Omadacycline against Rapidly Growing Mycobacteria

Antimicrob Agents Chemother. 2019 Apr 25;63(5):e02522-18. doi: 10.1128/AAC.02522-18. Print 2019 May.

Authors

Carolyn Shoen¹, David Benaroch², Mary Sklaney², Michael Cynamon¹

Affiliations

¹ Central New York Research Corporation, Syracuse, New York, USA shoenc@cnyrc.org Michael.Cynamon@va.gov.
² Central New York Research Corporation, Syracuse, New York, USA.

Abstract

The in vitro activity of omadacycline, a new tetracycline derivative, was evaluated against isolates of Mycobacterium abscessus, Mycobacterium chelonae, and Mycobacterium fortuitum using a broth microtiter dilution assay. Omadacycline had MIC₉₀ values of 2 μg/ml, 0.25 μg/ml, and 0.5 μg/ml, respectively. The in vitro activity of omadacycline against rapidly growing mycobacteria indicates that it may have the potential to improve therapy for infections caused by these organisms.

Keywords: antimicrobials; in vitro; nontuberculous mycobacteria.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology*
Microbial Sensitivity Tests
Mycobacterium / drug effects*
Mycobacterium abscessus / drug effects
Mycobacterium chelonae / drug effects
Mycobacterium fortuitum / drug effects
Tetracyclines / pharmacology*

Substances

Anti-Bacterial Agents
Tetracyclines
omadacycline