The objective was to assess the variables related to the usage of cosmetic products among a representative sample of the Lebanese population, including self-perception, facial attractiveness satisfaction, body image, and self-esteem. This is a cross-sectional study, conducted between January 2018 and June 2018, which enrolled 2,072 female participants using a proportionate random sample from all Lebanese Mohafazat. The results of a linear regression, taking the customary cosmetic usage score as the dependent variable, showed that an increase in the self-esteem score (β = -0.21) and being of Muslim religion compared with Christianity (β = -1.39) were significantly associated with lower cosmetic usage score. On another hand, an increase in the appearance orientation (AO) score (β = 0.55) and having a high (β = 2.18) and an intermediate (β = 0.99) socioeconomic status compared with a low one were associated with a higher cosmetic usage score respectively. According to our study, the use of cosmetic products by Lebanese women is associated with many factors such as AO, self-esteem, socioeconomic status, religion, and marital status. These results can open a window to other studies that might consider the relationship between personality traits, depression, and anxiety with the frequency of makeup use.