Palladium-catalysed ligand-free reductive Heck cycloisomerisation of 1,6-en-α-chloro-enamides

Yangyang Hou; Jing Ma; Hongyi Yang; Edward A Anderson; Andy Whiting; Na Wu

doi:10.1039/c9cc00537d

Palladium-catalysed ligand-free reductive Heck cycloisomerisation of 1,6-en-α-chloro-enamides

Chem Commun (Camb). 2019 Mar 26;55(26):3733-3736. doi: 10.1039/c9cc00537d.

Authors

Yangyang Hou¹, Jing Ma, Hongyi Yang, Edward A Anderson, Andy Whiting, Na Wu

Affiliation

¹ State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Science, Guangxi Normal University, Gulin, Guangxi 541004, China. wuna07@gxnu.edu.cn.

PMID: 30855630
DOI: 10.1039/c9cc00537d

Abstract

The first example of an intramolecular hydroarylation of 1,6-en-α-chloro-enamides was achieved by a palladium-catalysed ligand-free reductive Heck cycloisomerisation with no competing Heck-cyclised by-product.