Advancement in TPL2-regulated innate immune response

Immunobiology. 2019 May;224(3):383-387. doi: 10.1016/j.imbio.2019.02.010. Epub 2019 Mar 5.

Abstract

Tumor progression locus 2 (TPL2) is a serine/threonine kinase that belongs to the MAP3K family. The activated TPL2 regulates the innate immune-relevant signaling pathways, such as ERK, JNK, and NF-κB, and the differentiation of immune cells, for example, CD4+ T and NK cells. Therefore, TPL2 plays a critical role in regulating the innate immune response. The present review summarizes the recent advancements in the TPL2-regulated innate immune response.

Keywords: Innate immune; Regulation; Research progress; TPL2.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / immunology*
  • Cell Differentiation
  • Chemokines / metabolism
  • Humans
  • Immunity, Innate
  • MAP Kinase Kinase Kinases / genetics
  • MAP Kinase Kinase Kinases / metabolism*
  • MAP Kinase Signaling System
  • Macrophage Activation
  • Neutrophil Activation
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / metabolism*

Substances

  • Chemokines
  • Proto-Oncogene Proteins
  • MAP Kinase Kinase Kinases
  • MAP3K8 protein, human