Mapping In Vivo RNA Structures and Interactions

Jieyu Zhao; Xingyang Qian; Pui Yan Yeung; Qiangfeng Cliff Zhang; Chun Kit Kwok

doi:10.1016/j.tibs.2019.01.012

Mapping In Vivo RNA Structures and Interactions

Trends Biochem Sci. 2019 Jun;44(6):555-556. doi: 10.1016/j.tibs.2019.01.012. Epub 2019 Mar 7.

Authors

Jieyu Zhao¹, Xingyang Qian², Pui Yan Yeung¹, Qiangfeng Cliff Zhang³, Chun Kit Kwok⁴

Affiliations

¹ Department of Chemistry, City University of Hong Kong, Kowloon Tong, Hong Kong SAR, China; These authors contributed equally to this work.
² MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China; These authors contributed equally to this work.
³ MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China. Electronic address: qczhang@tsinghua.edu.cn.
⁴ Department of Chemistry, City University of Hong Kong, Kowloon Tong, Hong Kong SAR, China. Electronic address: ckkwok42@cityu.edu.hk.

PMID: 30853244
DOI: 10.1016/j.tibs.2019.01.012

Abstract

RNA folds to form diverse secondary and tertiary structures and often interacts with other biomolecules to function in cells. The technologies developed to map in vivo RNA structures and interactions can be broadly classified into four categories.

Keywords: RNA interactions; RNA structure; mass spectroscopy; next-generation sequencing.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

DNA / chemistry
Nucleic Acid Conformation
RNA / chemistry*
Sequence Analysis, RNA*

Substances

RNA
DNA