Near-Infrared Spectroscopy in the Diagnostic Evaluation of Mitochondrial Disorders: A Neonatal Intensive Care Unit Case Series

J Pediatr. 2019 May:208:282-286. doi: 10.1016/j.jpeds.2019.01.022. Epub 2019 Mar 8.

Abstract

We assessed the utility of near-infrared spectroscopy to evaluate neonates with mitochondrial disorders. We observed abnormally high cerebral oxygen saturation levels indicating insufficient tissue oxygen utilization. We propose that near-infrared spectroscopy may be an additional tool in the diagnostic evaluation of a suspected mitochondrial disorder.

Keywords: NIRS; lactic acidosis; mitochondrial; respiratory chain; spectroscopy.

Publication types

  • Case Reports

MeSH terms

  • Brain / diagnostic imaging
  • Cerebrovascular Circulation
  • Electroencephalography
  • Female
  • Gestational Age
  • Humans
  • Infant, Newborn
  • Intensive Care Units, Neonatal*
  • Intensive Care, Neonatal
  • Lactic Acid / blood
  • Male
  • Mitochondrial Diseases / diagnostic imaging*
  • Mitochondrial Diseases / genetics
  • Oximetry
  • Oxygen / metabolism
  • Perfusion
  • Spectroscopy, Near-Infrared*

Substances

  • Lactic Acid
  • Oxygen