Current treatment of behavioral and cognitive symptoms of Parkinson's disease

Abstract

Cognitive and behavioral symptoms are common in Parkinson's disease, may occur even in the prodromal stages of the disease, worsen with disease progression, and surpass motor symptoms as the major factors affecting patient quality of life and caregiver burden. The symptoms may be caused by the disease pathology or they may represent adverse effects of treatment, or both etiological factors may contribute. Although many of these symptoms are related to dopaminergic dysfunction or dopaminergic medication, other neurotransmitters are involved as well. Behavioral symptoms including impulse control disorders, apathy, psychosis, as well as mild cognitive impairment and dementia are reviewed with a special focus on current treatment approaches.

Keywords: Apathy; Behavioral; Cognitive; Dementia; Dopaminergic; Impulse control disorders; Mild cognitive impairment; Parkinson's disease; Psychosis; treatment.