Enhanced cytotoxicity of gold porphyrin complexes after inclusion in cyclodextrin scaffolds adsorbed on polyethyleneimine-coated gold nanoparticles

Bioorg Med Chem Lett. 2019 May 1;29(9):1065-1068. doi: 10.1016/j.bmcl.2019.03.003. Epub 2019 Mar 4.

Abstract

A new gold nanoparticle-based construct has been designed to hydrophobic drugs delivery into cancer cells. Cyclodextrin scaffolds adsorbed on polyethyleneimine-coated gold nanoparticles (AuNP@PEI@CD) have been used to encapsulate hydrophobic tetrapyrrolic compounds consisting of gold complexes of 5,10,15,20-tetraphenyl porphyrin (AuTPPCl) and 5-(4-acetoxyphenyl)-10,15,20-triphenyl porphyrin (AuTPPOAcCl). These two nanoparticles have been tested for their cytotoxic activities against the two colorectal cancer cell lines HT-29 and HCT-116 and have shown significant increases in toxicity when compared to the corresponding non-vectorized tetrapyrrolic macrocycles.

Keywords: Colorectal cancer; Gold nanoparticles; Gold porphyrins; Microwave; PEI.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adsorption
  • Cell Line, Tumor / drug effects
  • Coordination Complexes / chemistry*
  • Coordination Complexes / pharmacology
  • Cyclodextrins / chemistry*
  • Gold / chemistry*
  • Humans
  • Metal Nanoparticles / chemistry*
  • Metal Nanoparticles / toxicity
  • Polyethyleneimine / chemistry*
  • Porphyrins / chemistry

Substances

  • Coordination Complexes
  • Cyclodextrins
  • Porphyrins
  • Gold
  • Polyethyleneimine