Performance of Shear Wave Elastography in Delineating the Radiofrequency Ablation Boundary: An in Vivo experiment

Liya Su; Wenshuo Tian; Ming Xu; Manxia Lin; Bowen Zhuang; Tongyi Huang; Jieyi Ye; Mingde Lv; Xiaoyan Xie

doi:10.1016/j.ultrasmedbio.2019.01.016

Performance of Shear Wave Elastography in Delineating the Radiofrequency Ablation Boundary: An in Vivo experiment

Ultrasound Med Biol. 2019 May;45(5):1324-1330. doi: 10.1016/j.ultrasmedbio.2019.01.016. Epub 2019 Mar 6.

Authors

Liya Su¹, Wenshuo Tian¹, Ming Xu¹, Manxia Lin¹, Bowen Zhuang¹, Tongyi Huang¹, Jieyi Ye¹, Mingde Lv¹, Xiaoyan Xie²

Affiliations

¹ Department of Medical Ultrasound, First Affiliated Hospital, Institute of Diagnostic and Interventional Ultrasound, Sun Yat-Sen University, Guangzhou, China.
² Department of Medical Ultrasound, First Affiliated Hospital, Institute of Diagnostic and Interventional Ultrasound, Sun Yat-Sen University, Guangzhou, China. Electronic address: xxy1992sys@163.com.

PMID: 30851952
DOI: 10.1016/j.ultrasmedbio.2019.01.016

Abstract

This study was aimed at exploring the cutoff value of Young's modulus of ablated tissue and the optimal scale at which shear wave elastography (SWE) can delineate the ablation boundary. The livers of 30 rabbits were radiofrequency (RF) ablated, and ultrasonic imaging, including SWE and contrast-enhanced ultrasound (CEUS), was performed. The ablation boundary in the SWE image was located using CEUS, and the SWE parameters of the boundary were measured to calculate the cutoff value of Young's modulus. The cutoff value of the ablated tissue was 48-50 kPa 2 h to 28 d post-ablation. The regions of increased stiffness in SWE images at a scale of 0-50 kPa overlapped well with the non-enhanced regions of CEUS images in 88% of specimens. Therefore, elasticity values differed significantly between ablated and non-ablated tissues, and the cutoff value for Young's modulus differentiated these tissues. SWE delineated the ablation boundary well at the optimal SWE scale with respect to the cutoff value.

Keywords: Liver; Radiofrequency ablation; Shear wave elastography; Ultrasound.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Catheter Ablation / methods*
Elastic Modulus
Elasticity Imaging Techniques / methods*
Liver / diagnostic imaging*
Liver / surgery*
Models, Animal
Rabbits