Metabolic regulation of inflammasomes in inflammation

Immunology. 2019 Jun;157(2):95-109. doi: 10.1111/imm.13056. Epub 2019 Apr 8.

Abstract

Inflammasome activation and subsequent inflammatory cytokine secretion are essential for innate immune defence against multiple stimuli and are regarded as a link to adaptive immune responses. Dysfunction of inflammasome activation has been discovered at the onset or progression of infectious diseases, autoimmune diseases and cancer, all of which are also associated with metabolic factors. Furthermore, many studies concerning the metabolic regulation of inflammasome activation have emerged in recent years, especially regarding the activity of the NLRP3 inflammasome under metabolic reprogramming. In this review, we discuss the molecular mechanisms of the interactions between metabolic pathways and inflammasome activation, which exerts further important effects on various diseases.

Keywords: cancer progression; inflammasome; inflammation; innate immunity; macrophages; metabolic reprogramming; signalling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / metabolism*
  • Autoimmune Diseases / pathology
  • Cytokines / metabolism
  • Humans
  • Infections / metabolism*
  • Infections / pathology
  • Inflammasomes / metabolism*
  • Inflammation / metabolism
  • Inflammation / pathology
  • NLR Family, Pyrin Domain-Containing 3 Protein / metabolism
  • Neoplasm Proteins / metabolism
  • Neoplasms / metabolism*
  • Neoplasms / pathology

Substances

  • Cytokines
  • Inflammasomes
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • NLRP3 protein, human
  • Neoplasm Proteins