Manganese doped CdS sensitized graphene/Cu2MoS4 composite for the photoelectrochemical immunoassay of cardiac troponin I

Biosens Bioelectron. 2019 May 1:132:1-7. doi: 10.1016/j.bios.2019.02.048. Epub 2019 Feb 27.

Abstract

As a newly emerged photoactive material, Cu2MoS4 has motivated wide research interests in the field of photoelectrochemistry. Based on manganese doped CdS (CdS:Mn) sensitized graphene (G)/Cu2MoS4 composite, we developed a label-free photoelectrochemical (PEC) immunosensor for the detection of cardiac troponin I (cTnI). G as an excellent 2D conductive material, combined with Cu2MoS4 could improve its charge transfer efficiency. CdS:Mn nanoparticles (NPs) loaded on G/Cu2MoS4 further enlarged the light absorption range of Cu2MoS4 and restrained the electron-hole pairs recombination. Under optimal conditions, the proposed PEC immunosensor responded sensitively to cTnI with a low detection limit of 0.18 pg/mL and a wide linear range (0.005-1000 ng/mL). Moreover, as-fabricated immunosensor also exhibited high sensitivity, excellent selectivity and good stability. This work also was extended to real samples analysis and obtained satisfied results.

Keywords: Cardiac troponin I; G/Cu(2)MoS(4)@CdS:Mn composite; Label-free immunosensor; Mn doped CdS; Photoelectrochemistry.

Publication types

  • Evaluation Study

MeSH terms

  • Antibodies, Immobilized / chemistry*
  • Biosensing Techniques / methods*
  • Cadmium Compounds / chemistry*
  • Copper / chemistry
  • Electrochemical Techniques / methods*
  • Graphite / chemistry
  • Humans
  • Immunoassay / methods
  • Limit of Detection
  • Manganese / chemistry*
  • Molybdenum / chemistry
  • Nanoparticles / chemistry
  • Sulfides / chemistry*
  • Troponin I / blood*

Substances

  • Antibodies, Immobilized
  • Cadmium Compounds
  • Sulfides
  • Troponin I
  • cadmium sulfide
  • Manganese
  • Graphite
  • Copper
  • Molybdenum