Perinatal deaths after sildenafil treatment of fetal growth restriction raise the issue of safety in randomised clinical trials

MeSH terms

• Drug Interactions
• Female
• Fetal Growth Retardation / drug therapy*
• Humans
• Infant, Newborn
• Infant, Small for Gestational Age
• Multicenter Studies as Topic / standards
• Patient Safety / standards*
• Perinatal Death*
• Phosphodiesterase 5 Inhibitors / administration & dosage
• Phosphodiesterase 5 Inhibitors / adverse effects*
• Phosphodiesterase 5 Inhibitors / pharmacokinetics
• Pregnancy
• Randomized Controlled Trials as Topic / standards
• Research Design / standards
• Sildenafil Citrate / administration & dosage
• Sildenafil Citrate / adverse effects*
• Sildenafil Citrate / pharmacokinetics
• Vasodilator Agents / administration & dosage
• Vasodilator Agents / pharmacokinetics