Psoriasis is an inflammatory skin disease associated with increased cardiovascular risk and serves as a reliable model to study inflammatory atherogenesis. Because neutrophils are implicated in atherosclerosis development, this study reports that the interaction among low-density granulocytes, a subset of neutrophils, and platelets is associated with a noncalcified coronary plaque burden assessed by coronary computed tomography angiography. Because early atherosclerotic noncalcified burden can lead to fatal myocardial infarction, the low-density granulocyte-platelet interaction may play a crucial target for clinical intervention.
Keywords: CCTA, coronary computed tomography angiography; CVD, cardiovascular disease; FDR, false discovery rate; HAoEC, human aortic endothelial cell; LDG, low-density granulocyte; MI, myocardial infarction; NCB, noncalcified coronary plaque burden; NDG, normal-density granulocyte; NET, neutrophil extracellular trap; PASI, psoriasis area severity index; SLE, systemic lupus erythematosus; TB, total coronary plaque burden; cardiovascular disease; low-density granulocytes; neutrophils; platelets; psoriasis.