Poorly differentiated cutaneous squamous cell carcinoma with osteoclast-like giant cell: A rare, aggressive variant

Victoria L Venning; Esther Myint; John Pyne; Simon Clark

doi:10.1002/ccr3.1955

Poorly differentiated cutaneous squamous cell carcinoma with osteoclast-like giant cell: A rare, aggressive variant

Clin Case Rep. 2019 Jan 9;7(2):340-342. doi: 10.1002/ccr3.1955. eCollection 2019 Feb.

Authors

Victoria L Venning¹, Esther Myint^{1

2}, John Pyne^{3

4}, Simon Clark^{2

4}

Affiliations

¹ The Skin Hospital Sydney New South Wales Australia.
² Anatomical Pathology Douglass Hanly Moir Pathology Sydney New South Wales Australia.
³ Faculty of Medicine The University of Queensland Queensland Australia.
⁴ Faculty of Medicine University of New South Wales Sydney New South Wales Australia.

Abstract

Squamous Cell Carcinoma (SCC) with Osteoclast-like giant cell (OLGC) is a rare SCC variant; only 10 cases have been reported. Our case suggests OLGC are resultant of a reactive process, driven by the fusion of adjacent macrophages. Knowledge regarding SCC with OLGC is of great importance as this entity has greater prometastatic potential compared to conventional SCC.

Keywords: osteoclast‐like giant cells; skin cancer; squamous cell carcinoma.

Publication types

Case Reports