Chlorogenic acid alleviates obesity and modulates gut microbiota in high-fat-fed mice

Zhengyu Wang; Ka-Lung Lam; Jiamiao Hu; Shenghan Ge; Arong Zhou; Baodong Zheng; Shaoxiao Zeng; Shaoling Lin

doi:10.1002/fsn3.868

Chlorogenic acid alleviates obesity and modulates gut microbiota in high-fat-fed mice

Food Sci Nutr. 2019 Jan 28;7(2):579-588. doi: 10.1002/fsn3.868. eCollection 2019 Feb.

Authors

Zhengyu Wang^{1

2}, Ka-Lung Lam³, Jiamiao Hu^{1

2}, Shenghan Ge^{1

2}, Arong Zhou^{1

2}, Baodong Zheng^{1

2}, Shaoxiao Zeng¹, Shaoling Lin^{1

2}

Affiliations

¹ College of Food Science Fujian Agriculture and Forestry University Fuzhou China.
² Fujian Provincial Key Laboratory of Quality Science and Processing Technology in Special Starch Fujian Agriculture and Forestry University Fuzhou China.
³ School of Life Sciences The Chinese University of Hong Kong Shatin Hong Kong S.A.R. China.

Abstract

To evaluate the anti-obesity effects of chlorogenic acid (CGA), the mice were fed a high-fat diet (HFD) upon chlorogenic acid treatment for 6 weeks. The results showed administration of chlorogenic acid (150 mg per kg per day) remarkably promoted body loss, reduced lipid levels in plasma and altered mRNA expression of lipogenesis and lipolysis related genes in adipose tissue. Moreover, chlorogenic acid also reversed the HFD-induced gut microbiota dysbiosis, including significantly inhibiting the growth of Desulfovibrionaceae, Ruminococcaceae, Lachnospiraceae, Erysipelotrichaceae, and raising the growth of Bacteroidaceae, Lactobacillaceae. Overall, the amelioration of HFD-induced gut microbiota dysbiosis by chlorogenic acid may contribute, at least partially, to its beneficial effects on ameliorating HFD-induced obesity.

Keywords: body weight; chlorogenic acid; gut microbiota; obesity.