Analysis of Histological Grade in Resected Lung-invasive Adenocarcinoma

Abstract

Background/aim: Although the histological grading systems (Grading) with respect to lung adenocarcinoma are defined using architectural approaches in the eighth cancer Tumor, Node, and Metastasis (TNM) Classification, the prognostic value of the architectural subtypes in advanced stages of the disease remains unclear. We aimed to assess which Grading was more suitable as a prognostic factor: i) (conventional) Grading based on differentiation or ii) (new) Grading based on architectural subtypes.

Patients and methods: We analyzed the outcomes and Gradings of resected 449 patients with adenocarcinoma using receiver operating characteristic (ROC) curves.

Results: The tumor histological grade of 147 out of 449 patients changed using the results from the revised Grading. In these 147 patients, ROC curves showed that the area under the curve was 0.710 using the conventional Grading and 0.567 using the new Grading.

Conclusion: The conventional Grading might be more suitable for lung adenocarcinoma recurrence compared to the new Grading.

Keywords: Lung adenocarcinoma; histological grade; prognosis.