A New Transkingdom Dimension to NO Signaling

Dali Ma; François Leulier

doi:10.1016/j.cmet.2019.02.008

A New Transkingdom Dimension to NO Signaling

Cell Metab. 2019 Mar 5;29(3):513-515. doi: 10.1016/j.cmet.2019.02.008.

Authors

Dali Ma¹, François Leulier²

Affiliations

¹ Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Ecole Normale Supérieure de Lyon, CNRS UMR5242, UCBL1, Lyon, France. Electronic address: dali.ma@ens-lyon.fr.
² Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Ecole Normale Supérieure de Lyon, CNRS UMR5242, UCBL1, Lyon, France. Electronic address: francois.leulier@ens-lyon.fr.

PMID: 30840909
DOI: 10.1016/j.cmet.2019.02.008

Abstract

Bacterial-derived metabolites profoundly influence the host's cellular and organismal physiology. Seth et al. (2019) report that via interspecies S-nitrosylation, microbiota-derived nitric oxide directly alters the host's Argonaute family protein activity, and consequently impinges on the overall post-transcriptional gene silencing program through the microRNA (miRNA) machinery.

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Comment

MeSH terms

Argonaute Proteins
MicroRNAs*
Nitric Oxide*
RNA Interference
Signal Transduction

Substances

Argonaute Proteins
MicroRNAs
Nitric Oxide