The sedimentation of a charge-regulating porous sphere surrounded by an arbitrary electric double layer, which usually models a permeable polyelectrolyte coil or an aggregate of nanoparticles, is analyzed for the first time. The hydrodynamic frictional segments and ionogenic functional groups uniformly distribute in the porous sphere, and a regulation mechanism for the dissociation and association reactions occurring at these functional groups linearly relates the local electric potential to fixed charge density. The linearized electrokinetic equations governing the ionic concentration (or electrochemical potential energy), electric potential, and fluid velocity fields are solved for the case of a small basic fixed charge density by the regular perturbation method. Analytical formulae for the sedimentation velocity of a porous sphere and sedimentation potential of a dilute suspension of porous spheres are then obtained. The charge regulation tends to reduce the electrokinetic retardation to sedimentation velocity and the sedimentation potential (can be as much as 50 and 25%, respectively) compared to the case that the fixed charge density is a constant. Both the electrokinetic retardation to sedimentation velocity and the sedimentation potential vanish at the isoelectric point of the particles. The increase in the bulk concentration of the potential-determining ions crossing the isoelectric point changes signs of the fixed charges and thus causes a reversal in the direction of the sedimentation potential. The effects of charge regulation on the sedimentation of porous particles differ substantially from those of hard particles.