Identification, Review, and Use of Health State Utilities in Cost-Effectiveness Models: An ISPOR Good Practices for Outcomes Research Task Force Report

John Brazier; Roberta Ara; Ismail Azzabi; Jan Busschbach; Hélène Chevrou-Séverac; Bruce Crawford; Luciane Cruz; John Karnon; Andrew Lloyd; Suzy Paisley; A Simon Pickard

doi:10.1016/j.jval.2019.01.004

Identification, Review, and Use of Health State Utilities in Cost-Effectiveness Models: An ISPOR Good Practices for Outcomes Research Task Force Report

Value Health. 2019 Mar;22(3):267-275. doi: 10.1016/j.jval.2019.01.004.

Authors

Affiliations

¹ University of Sheffield, Sheffield, South Yorkshire, UK. Electronic address: j.e.brazier@sheffield.ac.uk.
² University of Sheffield, Sheffield, South Yorkshire, UK.
³ Takeda Pharmaceutical International AG, Zurich, Switzerland.
⁴ Erasmus University Medical Center, Rotterdam, The Netherlands; Viersprong Institute for Studies of Personality Disorders, Halsteren, The Netherlands.
⁵ Celgene International Sàrl, Boudry, Switzerland.
⁶ APAC, Syneos Health, Tokyo, Japan.
⁷ Health Technology Assessment Institute, Federal University of Rio Grande du Sol, Porto Alegre, Brazil.
⁸ The University of Adelaide, Adelaide, Australia.
⁹ Acaster Lloyd Consulting Ltd, Oxford, UK.
¹⁰ Department of Pharmacy Systems, Outcomes and Policy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.

PMID: 30832964
DOI: 10.1016/j.jval.2019.01.004

Abstract

Cost-effectiveness models that present results in terms of cost per quality-adjusted life-year for health technologies are used to inform policy decisions in many parts of the world. Health state utilities (HSUs) are required to calculate the quality-adjusted life-years. Even when clinical studies assessing the effectiveness of health technologies collect data on HSUs to populate a cost-effectiveness model, which rarely happens, analysts typically need to identify at least some additional HSUs from alternative sources. When possible, HSUs are identified by a systematic review of the literature, but, again, this rarely happens. In 2014, ISPOR established a Good Practices for Outcome Research Task Force to address the use of HSUs in cost-effectiveness models. This task force report provides recommendations for researchers who identify, review, and synthesize HSUs for use in cost-effectiveness models; analysts who use the results in models; and reviewers who critically appraise the suitability and validity of the HSUs selected for use in models. The associated Minimum Reporting Standards of Systematic Review of Utilities for Cost-Effectiveness checklist created by the task force provides criteria to judge the appropriateness of the HSUs selected for use in cost-effectiveness models and is suitable for use in different international settings.

Keywords: cost effectiveness; economic evaluation; health state utility; preference-based; quality of life; systematic reviews; utilities.

Publication types

Review

MeSH terms

Advisory Committees* / trends
Cost-Benefit Analysis / methods*
Cost-Benefit Analysis / trends
Health Status Indicators
Humans
Outcome Assessment, Health Care / methods*
Outcome Assessment, Health Care / trends
Patient Acceptance of Health Care
Quality-Adjusted Life Years*
Research Report* / trends
Technology Assessment, Biomedical / methods*
Technology Assessment, Biomedical / trends