C9orf72 deficiency promotes motor deficits of a C9ALS/FTD mouse model in a dose-dependent manner

Acta Neuropathol Commun. 2019 Mar 4;7(1):32. doi: 10.1186/s40478-019-0685-7.
No abstract available

Keywords: C9ALS/FTD; C9orf72; Mice; Motor deficits.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyotrophic Lateral Sclerosis / genetics*
  • Amyotrophic Lateral Sclerosis / metabolism
  • Animals
  • C9orf72 Protein / deficiency*
  • C9orf72 Protein / genetics*
  • Disease Models, Animal*
  • Female
  • Frontotemporal Dementia / genetics*
  • Frontotemporal Dementia / metabolism
  • Gene Dosage / physiology*
  • Humans
  • Male
  • Mice
  • Mice, Transgenic

Substances

  • C9orf72 Protein
  • C9orf72 protein, mouse