γδ T lymphocytes in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis

Michał K Zarobkiewicz; Wioleta Kowalska; Jacek Roliński; Agnieszka A Bojarska-Junak

doi:10.1016/j.jneuroim.2019.02.009

γδ T lymphocytes in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis

J Neuroimmunol. 2019 May 15:330:67-73. doi: 10.1016/j.jneuroim.2019.02.009. Epub 2019 Feb 18.

Authors

Michał K Zarobkiewicz¹, Wioleta Kowalska², Jacek Roliński², Agnieszka A Bojarska-Junak²

Affiliations

¹ Chair and Department of Clinical Immunology, Medical University of Lublin, Poland. Electronic address: michal.zarobkiewicz@gmail.com.
² Chair and Department of Clinical Immunology, Medical University of Lublin, Poland.

PMID: 30831520
DOI: 10.1016/j.jneuroim.2019.02.009

Abstract

The aim of the current review is to summarize the results of studies on the role of γδ T cells in the pathogenesis of multiple sclerosis and its animal model - the experimental autoimmune encephalomyelitis. Despite the fact that numerous studies have been performed, the role of γδ T is still not fully understood. It seems that there are two distinct subpopulations - one exacerbating the disease (IL-17-producing) and the other playing a protective role (IFN-γ-secreting). Nevertheless, future studies are required for an understanding of γδ T cells role in multiple sclerosis.

Keywords: EAE; Experimental autoimmune encephalomyelitis; IL-17; MS; Multiple sclerosis; γδ T cells.

Publication types

Review

MeSH terms

Animals
Encephalomyelitis, Autoimmune, Experimental / immunology*
Encephalomyelitis, Autoimmune, Experimental / metabolism*
Humans
Intraepithelial Lymphocytes / immunology*
Intraepithelial Lymphocytes / metabolism*
Multiple Sclerosis / immunology*
Multiple Sclerosis / metabolism*