Mini-review: Targeted radiopharmaceuticals incorporating reversible, low molecular weight albumin binders

Abstract

The combination of low molecular weight, reversible human serum albumin (HSA) binders with targeted radiopharmaceuticals in dual-targeted radioconjugates holds great promise, in particular for endoradiotherapy. Attachment of HSA-binders to radiopharmaceuticals extends their blood circulation time and results in an enhanced tumour uptake as well as often in an improved pharmacokinetic profile. In this mini-review, an overview of currently pursued approaches of this novel strategy is provided.

Keywords: Albumin binder; Blood circulation time; Dual-targeted radioconjugates; Endoradiotherapy; Human serum albumin; Targeted radiopharmaceuticals.