The "three certificates and three methods" is a combination of Chinese and Western medicine for the treatment of sepsis proposed by Professor Wang Jinda, a pioneer in Chinese emergency medicine. The "Wei Qi Ying Xue" syndrome differentiation is a dialectical theory proposed by Ye Tianshi, a famous doctor in the Qing Dynasty, for the treatment of warm diseases. The "three certificates and three methods" theory of "toxin-heat syndrome" (inflammation storm) to the "blood stasis syndrome" (coagulation storm) conversion mainly focus on the "Wei Qi Ying Xue" syndrome differentiation of the "Wei, Qi syndrome" to "Ying, Xue syndrome", and poison. The conversion of "toxin-heat syndrome" to "blood stasis syndrome" is a watershed in the progression of common infections to sepsis. The timely application of Xuebijing injection can cut off this transformation, which is one of the reasons why Xuebijing injection can treat sepsis.