Enhanced osteoconductivity on electrically charged titanium implants treated by physicochemical surface modifications methods

Marc Fernández-Yagüe; Roman Perez Antoñanzas; Joan Josep Roa; Manus Biggs; F Javier Gil; Marta Pegueroles

doi:10.1016/j.nano.2019.02.005

Enhanced osteoconductivity on electrically charged titanium implants treated by physicochemical surface modifications methods

Nanomedicine. 2019 Jun:18:1-10. doi: 10.1016/j.nano.2019.02.005. Epub 2019 Feb 26.

Authors

Marc Fernández-Yagüe¹, Roman Perez Antoñanzas², Joan Josep Roa³, Manus Biggs⁴, F Javier Gil⁵, Marta Pegueroles⁶

Affiliations

¹ Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering, Technical University of Catalonia (UPC), EEBE, Barcelona, Spain; CURAM, Centre for Medical Devices. National University of Ireland, Galway, Galway, Ireland.
² Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering, Technical University of Catalonia (UPC), EEBE, Barcelona, Spain; Bioengineering Institute of Technology, School of Dentistry, Universitat Internacional de Catalunya, Barcelona, Spain.
³ Structural Integrity, Micromechanics and Materials Reliability, Department of Materials Science and Metallurgical Engineering, Technical University of Catalonia (UPC), EEBE, Barcelona, Spain.
⁴ CURAM, Centre for Medical Devices. National University of Ireland, Galway, Galway, Ireland.
⁵ Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering, Technical University of Catalonia (UPC), EEBE, Barcelona, Spain; Bioengineering Institute of Technology, School of Dentistry, Universitat Internacional de Catalunya, Barcelona, Spain. Electronic address: xavier.gil@uic.es.
⁶ Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering, Technical University of Catalonia (UPC), EEBE, Barcelona, Spain.

PMID: 30822556
DOI: 10.1016/j.nano.2019.02.005

Abstract

Biomimetic design is a key tenet of orthopedic device technology, and in particular the development of responsive surfaces that promote ion exchange with interfacing tissues, facilitating the ionic events that occur naturally during bone repair, hold promise in orthopedic fixation strategies. Non-bioactive nanostructured titanium implants treated by shot-blasting and acid-etching (AE) induced higher bone implant contact (BIC=52% and 65%) compared to shot-blasted treated (SB) implants (BIC=46% and 47%) at weeks 4 and 8, respectively. However, bioactive charged implants produced by plasma (PL) or thermochemical (BIO) processes exhibited enhanced osteoconductivity through specific ionic surface-tissue exchange (PL, BIC= 69% and 77% and BIO, BIC= 85% and 87% at weeks 4 and 8 respectively). Furthermore, bioactive surfaces (PL and BIO) showed functional mechanical stability (resonance frequency analyses) as early as 4 weeks post implantation via increased total bone area (BAT=56% and 59%) ingrowth compared to SB (BAT=35%) and AE (BAT=35%) surfaces.

Keywords: Bone repair; Electrical charges; Functionalization; Titanium; Topographies.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bone Regeneration / drug effects*
Chemical Phenomena*
Dental Implants*
Female
Interferometry
Static Electricity
Surface Properties
Swine
Swine, Miniature
Titanium / pharmacology*

Substances

Dental Implants
Titanium