Targeting cancer stem cells as therapeutic approach in the treatment of colorectal cancer

Int J Biochem Cell Biol. 2019 May:110:75-83. doi: 10.1016/j.biocel.2019.02.010. Epub 2019 Feb 25.

Abstract

Colorectal cancer is one of the most common cancers globally. A large portion of colorectal cancer patients who are treated with conventional chemotherapy eventually develop local recurrence or metastases. The failure of a complete cure in colorectal cancer patients may be related to the lack of complete eradication of cancer stem cells when using conventional therapy. Colorectal cancer stem cells comprise a small population of tumor cells that possess the properties of rapid proliferation and differentiation. The colorectal cancer stem cells are also phenotypically and molecularly distinct, and resistant to conventional chemo-radiotherapy. Therefore, it is important to identify approaches in combination with conventional therapy for targeting and eradicating cancer cells. The aim of this review was to summarize the main findings of recent studies on targeting colorectal cancer stem cells as a novel therapeutic approach in colorectal cancer treatment.

Keywords: Cancer stem cells; Colorectal cancer; Conventional; Target; Therapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Colorectal Neoplasms / drug therapy*
  • Colorectal Neoplasms / genetics
  • Colorectal Neoplasms / pathology*
  • Humans
  • MicroRNAs / genetics
  • Molecular Targeted Therapy / methods*
  • Neoplastic Stem Cells / drug effects*
  • Neoplastic Stem Cells / pathology
  • Signal Transduction / drug effects
  • Tumor Microenvironment / drug effects

Substances

  • MicroRNAs