Incidence and malignancy rates classified by The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) - An 8-year tertiary center experience in Thailand

Yotsapon Thewjitcharoen; Siriwan Butadej; Soontaree Nakasatien; Phawinpon Chotwanvirat; Sriurai Porramatikul; Sirinate Krittiyawong; Nampetch Lekpittaya; Thep Himathongkam

doi:10.1016/j.jcte.2018.12.004

Incidence and malignancy rates classified by The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) - An 8-year tertiary center experience in Thailand

J Clin Transl Endocrinol. 2018 Dec 14:16:100175. doi: 10.1016/j.jcte.2018.12.004. eCollection 2019 Jun.

Authors

Yotsapon Thewjitcharoen¹, Siriwan Butadej¹, Soontaree Nakasatien¹, Phawinpon Chotwanvirat¹, Sriurai Porramatikul¹, Sirinate Krittiyawong¹, Nampetch Lekpittaya¹, Thep Himathongkam¹

Affiliation

¹ Diabetes and Thyroid Center, Theptarin Hospital, Bangkok, Thailand.

Abstract

Incidence and Malignancy Rates Classified by The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) - An 8-year Tertiary Center experience in Thailand.

Background: Fine-needle aspiration (FNA) of the thyroid is considered the best diagnostic tool for preoperative evaluation of thyroid nodules. The introduction of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) in 2010 provided the opportunity to establish worldwide standard for reporting and terminology guidelines for diagnostic categories. It is recommended that every institution evaluates the risk of malignancy (ROM) in each category for quality improvement process.

Aim: To assess the effectiveness of TBSRTC method at our institution using cyto-histological correlation.

Method: A retrospective 8-year (2010-2017) audit of thyroid FNA done by thyroid specialists at Theptarin hospital. The FNA results were classified according to TBSRTC. Histopathology reports for operated cases were used to correlate cytology and final histopathology.

Results: A total of 2735 thyroid FNA from 2115 patients (mean age 45.7 ± 13.1 years, female 89.8%) were examined. The rates of non-diagnostic, benign, atypia of undetermined significance (AUS), follicular neoplasm, suspected for malignancy, and malignant cases were 21.1%, 66.6%, 4.7%, 2.4%, 1.8%, and 3.3% respectively. There were 188 patients (9%) who underwent surgical resection with available histopathology. Malignancy rates in operated thyroid nodules were 20.0%, 4.2%, 9.4%, 23.5%, 57.1%, and 90.3% for categories 1 to 6, respectively. The sensitivity, specificity, negative predictive value, and positive predictive value were 96.6%, 88.5%, 95.8%, and 90.3, respectively.

Conclusions: Preoperative diagnosis of thyroid nodules using TBSRTC in our hospital was comparable with other studies. The uniform diagnostic criteria of the Bethesda System help avoid misinterpretation while sharing local experience with international benchmarks.

Keywords: Fine-needle aspiration (FNA); Risk of malignancy (ROM); Thailand; The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC).