Incidence of Side-effects After Weekly Iron and Folic Acid Consumption Among School-going Indian Adolescents

Indian Pediatr. 2019 Jan 15;56(1):33-36.

Abstract

Objective: To estimate incidence of side effects after weekly iron and folic acid supplementation (WIFS) in Delhi and Haryana.

Methods: In this cross-sectional school-based study, data were collected from 4,183 adolescents on WIFS consumption and side effects experienced first time of receipt of WIFS (week 1), and in last two consecutive weeks (week 2,3). Week 3 was 48 hours preceding the survey.

Results: WIFS consumption in week 1, 2 and 3 was 85%, 63% and 52%, respectively. Side effects reported were highest in first week (25%) and reduced to 7% (week 2) and 5% (week 3). Side effects most reported were abdominal pain (80%) and nausea (10%). Adolescents (45%) who faced a side-effect in week 1 did not consume WIFS in subsequent week.

Conclusions: Incidence of side effects was low, but it affected compliance. Positive reinforcement to students who face side effects requires strengthening by teachers.

MeSH terms

  • Abdominal Pain / epidemiology
  • Abdominal Pain / etiology
  • Adolescent
  • Anemia, Iron-Deficiency / drug therapy
  • Cross-Sectional Studies
  • Dietary Supplements / adverse effects*
  • Dietary Supplements / statistics & numerical data
  • Female
  • Folic Acid / administration & dosage
  • Folic Acid / adverse effects*
  • Folic Acid / therapeutic use
  • Humans
  • Incidence
  • India / epidemiology
  • Iron / administration & dosage
  • Iron / adverse effects*
  • Iron / therapeutic use
  • Male
  • Nausea / epidemiology
  • Nausea / etiology
  • Patient Compliance / statistics & numerical data
  • Students

Substances

  • Folic Acid
  • Iron